The mission of the 114th Maintenance Group is to ensure that assigned aircraft and equipment are safe, serviceable, and properly configured to meet mission requirements. Maintenance actions include, but are not limited to, inspection, repair, overhaul, modification, preservation, refurbishment, testing, and analyzing condition and performance.

The mission of the 114th Mission Support Group is to direct the activities of the 114th Mission Support Flight, 114th Civil Engineer Squadron, 114th Security Forces Squadron, 114th Communications Flight, 114th Logistics Readiness Squadron, and the 114th Services Flight toward the overall missions and objectives of the 114th Fighter Wing.

The mission of the 114th Operations Group is to deploy worldwide and execute directed tactical fighter sorties to destroy enemy forces, supplies, equipment, communications systems and installations with conventional weapons.

The mission of the 114th Medical Group is, upon mobilization, to provide manpower replacement tasking by the gaining major command, Air Combat Command. The 114th Medical Group provides limited health services for approximately 1,000 personnel assigned to the 114th Fighter Wing.

The mission of Headquarters, South Dakota Air National Guard is to prepare plans, policies, and programs for Air National Guard units assigned to the State; to advise and assist the Adjutant General in execution of these plans; and assist in the administration, logistics, and training of Air National Guard units.